Xin Lu

Xin Lu is a cancer biologist distinguished by her contributions to understanding cellular pathways that control cell fate in development and disease, particularly cancer. She has a long-standing interest in how to selectively kill cancer cells, and her major research advances have provided insights into how p53, the most mutated or inactivated tumour suppressor in human cancers, can make life or death decisions for a cell.

 

Xin’s early work showed how p53 responds to activation of cancer-causing genes and DNA damage. She then discovered the ASPP family of proteins as molecular switches that control p53-mediated cell killing. In addition to cancer, the ASPPs have now been implicated in the pathogenesis of other disorders, including sudden cardiac death and brain abnormalities. Xin has also made contributions to our understanding of fundamental cell biology through her ongoing research on the role of cell plasticity in cancer.

 

Xin is a Fellow of the Academy of Medical Sciences and of the Royal Society of Biology, and a Member of the European Molecular Biology Organisation.