Integrating Sex and Gender in Biomedical, Health, and Care Research 11th December 2023 The Academy of Medical Sciences emphasizes the critical importance of integrating sex and gender considerations into biomedical, health, and care research. Recognizing that biological sex and gender identity significantly influence health outcomes, the Academy advocates for research practices that account for these variables to ensure more accurate, equitable, and applicable results. By incorporating sex and gender analysis, researchers can uncover differences in disease presentation, treatment responses, and health behaviors, ultimately leading to more personalized and effective healthcare. Enhancing Research Accuracy and Relevance Incorporating sex and gender into research is essential for enhancing the accuracy and relevance of scientific findings. Historically, research has often overlooked these factors, leading to gaps in knowledge that can affect the generalizability of results. The Academy underscores the importance of designing studies that consider sex and gender from the outset, ensuring that research questions, methodologies, and analyses are appropriately tailored to reflect the diversity of human experiences. This approach not only improves the quality of research but also ensures that findings are applicable to all segments of the population. Addressing Health Disparities The Academy highlights the role of sex and gender integration in addressing health disparities. Differences in biology and social roles contribute to varying health risks and outcomes between sexes and genders, and failing to account for these differences can perpetuate inequities in healthcare. The Academy calls for a more nuanced understanding of how sex and gender intersect with other social determinants of health, such as race, socioeconomic status, and age, to inform more equitable health policies and interventions. Guidelines for Researchers To support the integration of sex and gender in research, the Academy provides guidelines for researchers, emphasizing the need for rigorous study design, data collection, and analysis that take these factors into account. The guidelines encourage researchers to disaggregate data by sex and gender, report findings in a sex- and gender-specific manner, and consider the implications of their results for different populations. By following these best practices, researchers can contribute to a more comprehensive understanding of health and disease. Collaborative Efforts and Advocacy The Academy also advocates for increased collaboration among researchers, funding bodies, and policymakers to promote the integration of sex and gender in research. By working together, these stakeholders can develop standards and frameworks that facilitate the consistent consideration of sex and gender across all areas of biomedical and health research. The Academy is committed to leading these efforts and ensuring that the importance of sex and gender in research is recognized at every level. Conclusion The Academy of Medical Sciences calls for the integration of sex and gender in all biomedical, health, and care research to enhance the accuracy, relevance, and equity of scientific findings. By adopting this approach, researchers can contribute to more personalized and effective healthcare for diverse populations.